Afimmune Initiates Epeleuton Phase IIb TRIAGE Study in Patients With High Triglycerides and Type 2 Diabetes
Data from Phase IIa show potent effect of Epeleuton on Triglyceride and HbA1C levels
Afimmune, a clinical stage drug discovery company focused on the development of biologically active polyunsaturated lipids for the treatment of cardiometabolic diseases, announced today the start of TRIAGE (TRIglyceride And Glucose control with Epeleuton in Metabolic Syndrome Patients), a Phase IIb study of epeleuton in patients with high triglycerides and type 2 diabetes. Epeleuton is a synthetic prodrug of an endogenous downstream metabolite of eicosapentaenoic acid (EPA).
“In a Phase IIa study in patients with non-alcoholic fatty liver disease (NAFLD), epeleuton not only significantly lowered triglycerides and cholesterol but also statistically and clinically significantly reduced HbA1c and fasting glucose,” said Dr. John Climax, CEO of Afimmune. “Beyond this epeleuton was found to be very safe with no treatment related serious adverse events. These data lead us to believe that epeleuton could