The question of what dosage of coq10 is sufficient for any health problem or simply for health maintenance is one that has been difficult for scientists to answer. The main reason for the difficulty has to do with bioavailability.
The bioavailability of a drug or a nutritional supplement has to do with the amount of that reaches the bloodstream when the compound is taken orally. Coenzyme Q10 has a relatively low bioavailability, which has led to the use of doses as high as 200-300mg per day in clinical studies.
Although no toxic effects have been seen after taking these high daily doses, the safety of their continued use has not been established. Some nutrients are known to be toxic at high doses. In laboratory studies, some antioxidants have been shown to cause oxidation, at high doses.
On the other hand, too little coenzyme Q10 in the bloodstream indicates too little … Read More